Reply to “Noncarbapenemase OXA-48 Variants (OXA-163 and OXA-405) Falsely Detected as Carbapenemases by the β Carba Test”
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چکیده
منابع مشابه
Noncarbapenemase OXA-48 Variants (OXA-163 and OXA-405) Falsely Detected as Carbapenemases by the β Carba Test.
Laurent Dortet, Thierry Naas Associated French National Reference Center for Antibiotic Resistance, Le Kremlin-Bicêtre, France; Research Unit EA7361 “Structure, Dynamic, Function and Expression of Broad Spectrum β-Lactamases,” Faculty of Medicine, University Paris-Sud, Le Kremlin-Bicêtre, France; Department of Bacteriology-Parasitology-Hygiene, Bicêtre Hospital, Assistance Publique—Hôpitaux de ...
متن کاملOXA-48-like carbapenemases: the phantom menace.
OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly reported in enterobacterial species. To date, six OXA-48-like variants have been identified, with OXA-48 being the most widespread. They differ by a few amino acid substitutions or deletions (one to five amino acids). The enzymes hydrolyse penicillins at a high level and carbapenems at a low level, sparing broad-spectrum c...
متن کاملNew Delhi metallo-β-lactamase and OXA-48 carbapenemases in Gram-negative bacilli isolates in Libya
To the Editor Carbapenems (i.e. ertapenem, imipenem, meropenem, and doripenem) are second line antimicrobials reserved to treat serious infections, including those caused by Gramnegative bacilli (GNB) producing extended-spectrum b-lactamses (ESBLs). ESBLs mediate resistance among GNB to b-lactam drugs, including third generation cephalosporins. Emergence of carbapenemases-producing GNB (mainly ...
متن کاملHeterogeneous hydrolytic features for OXA-48-like β-lactamases.
OBJECTIVES Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins. Recently, diverse OXA-48-like β-lactamases have been identified worldwide (OXA-162, OXA-181, OXA-163, OXA-204 and OXA-232). They differ by few...
متن کاملEvaluation of a new phenotypic OXA-48 disk test for differentiation of OXA-48 carbapenemase-producing Enterobacteriaceae clinical isolates.
The current phenotypic methods for detecting carbapenemase-producing Enterobacteriaceae (CPE) allow differentiation between class A and B carbapenemases, but they cannot confirm in a single test class D OXA-48 carbapenemase producers. In this study, we evaluated a new phenotypic test, the OXA-48 disk test, which is based on an imipenem disk and two blank disks adjacent to the imipenem disk, loa...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2017
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.02114-16